Aβ1–42 aggregation inhibitor 1

Name: Aβ1–42 aggregation inhibitor 1
Brand: MedChemExpress
SKU: HY-150003
Rating: 4.5 (0 reviews)

製品番号: HY-150003 純度: 99.19%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC₅₀ value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM. Aβ1-42 aggregation inhibitor 1 has the potential for the research of anti-Alzheimer's disease.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Aβ1–42 aggregation inhibitor 1 構造式

CAS 番号 : 2439107-75-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 222	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 222	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$215	在庫あり	Estimated Time of Arrival: December 31
10 mg	$345	在庫あり	Estimated Time of Arrival: December 31
25 mg	$690	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1100	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

AChE BChE

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC50: 2.64 μM (AChE), 1.29 μM (BuChE)^[1].

体外実験

Aβ1-42 aggregation inhibitor 1 (compound 50) (25 μM, 30 min) can selectively form ligand-Cu ²⁺ complexes with Cu²⁺^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.66

分子式

C₂₉H₃₂N₄S

CAS 番号

2439107-75-0

Appearance

Solid

Color

White to off-white

SMILES

CCN1C2=CC=C(/C=C/C3=CC=C(C=C3)NC(NCCN4CCCC4)=S)C=C2C5=CC=CC=C51

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (213.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1337 mL	10.6687 mL	21.3374 mL
5 mM	0.4267 mL	2.1337 mL	4.2675 mL
10 mM	0.2134 mL	1.0669 mL	2.1337 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.19%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (249 KB) HNMR (145 KB) RP-HPLC (246 KB) LCMS (105 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Dushyant V Patel, et al. Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents. Bioorg Chem. 2020 Aug;101:103977. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1337 mL	10.6687 mL	21.3374 mL	53.3436 mL
	5 mM	0.4267 mL	2.1337 mL	4.2675 mL	10.6687 mL
	10 mM	0.2134 mL	1.0669 mL	2.1337 mL	5.3344 mL
	15 mM	0.1422 mL	0.7112 mL	1.4225 mL	3.5562 mL
	20 mM	0.1067 mL	0.5334 mL	1.0669 mL	2.6672 mL
	25 mM	0.0853 mL	0.4267 mL	0.8535 mL	2.1337 mL
	30 mM	0.0711 mL	0.3556 mL	0.7112 mL	1.7781 mL
	40 mM	0.0533 mL	0.2667 mL	0.5334 mL	1.3336 mL
	50 mM	0.0427 mL	0.2134 mL	0.4267 mL	1.0669 mL
	60 mM	0.0356 mL	0.1778 mL	0.3556 mL	0.8891 mL
	80 mM	0.0267 mL	0.1334 mL	0.2667 mL	0.6668 mL
	100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5334 mL