AChE/MAO-IN-1

Art. -Nr.: HY-152109: Data Sheet Handling Instructions
FAQs
Technical Support

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively.

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AChE/MAO-IN-1 Chemische Struktur

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100 mg		Angebot einholen
250 mg		Angebot einholen
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This product is a controlled substance and not for sale in your territory.

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

AChE BChE

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

MAO-A MAO-B

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

AChE/MAO-IN-1 (Compound D28) is a potent AChE, MAO-A and MAO-B inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively^[1].

IC₅₀ & Target^[1]

hAChE

0.0248 μM (IC₅₀)

hMAO-B

0.0409 μM (IC₅₀)

hMAO-A

0.1069 μM (Ki)

hMAO-A

0.1108 μM (IC₅₀)

Aβ42

0.1467 μM (IC₅₀)

In Vitro

AChE/MAO-IN-1 (Compound D28) shows antioxidant activity with an IC₅₀ of 0.210 ± 0.010 μM in the DPPH free-radical scavenging activity test^[1].
AChE/MAO-IN-1 inhibits beta amyloid 1–42 (Aβ42) with an IC₅₀ of 0.1467 ± 0.0053 μM^[1].
AChE/MAO-IN-1 (24 h) shows low cytotoxicity against NIH/3T3 cells (IC₅₀: 6.5162 ± 0.1750 μM)^[1].
AChE/MAO-IN-1 can very effectively bind to the active site of the MAO-A enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	NIH/3T3 mouse fibroblast healthy cell line
Concentration:
Incubation Time:	24 h
Result:	Showed cytotoxicity with an IC₅₀ of 6.5162 ± 0.1750 μM.

Molekulargewicht

378.46

Formel

C₂₃H₂₆N₂O₃

SMILES

O=C(NC1=CC=C(/C=C(CC2=C3C=CC(OC)=C2)\C3=O)C=C1)CN(C)CCC

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sağlık BN, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. [Content Brief]

AChE/MAO-IN-1 Related Classifications

Neurological Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/MAO-IN-1Cholinesterase (ChE)Monoamine OxidaseAmyloid-βMAOβ-amyloid peptideAβAbetaantioxidantAlzheimer’s diseaselow cytotoxicityInhibitorinhibitorinhibit

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