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  4. Aciculatin

Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

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Aciculatin

Aciculatin Chemical Structure

CAS No. : 134044-97-6

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Aciculatin Related Antibodies

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Description

Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
2.65 μM
Compound: aciculatin
Cytotoxicity against human CEM cells after 48 hrs by alamar blue assay
Cytotoxicity against human CEM cells after 48 hrs by alamar blue assay
[PMID: 22272829]
HT-29 IC50
25.98 μM
Compound: aciculatin
Cytotoxicity against human HT-29 cells after 48 hrs by alamar blue assay
Cytotoxicity against human HT-29 cells after 48 hrs by alamar blue assay
[PMID: 22272829]
MCF7 IC50
3.16 μM
Compound: aciculatin
Cytotoxicity against human MCF7 cells after 48 hrs by alamar blue assay
Cytotoxicity against human MCF7 cells after 48 hrs by alamar blue assay
[PMID: 22272829]
NCI-H460 IC50
46.94 μM
Compound: aciculatin
Cytotoxicity against human NCI-H460 cells after 48 hrs by alamar blue assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by alamar blue assay
[PMID: 22272829]
Molecular Weight

414.41

Formula

C22H22O8
CAS No.
SMILES

COC1=CC(O)=C(C(C=C(C2=CC=C(C=C2)O)O3)=O)C3=C1[C@H]4C[C@@H]([C@@H]([C@H](O4)C)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aciculatin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aciculatin134044-97-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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Aciculatin
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HY-120529
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