Acid-PEG4-NHS ester
Based on 1 Customer Validation
Acid-PEG4-NHS ester is a PEG4-based PROTAC linker that can be used for the synthesis of PROTACs. Acid-PEG4-NHS ester contains a carboxylic acid and an NHS ester; the carboxylic acid reacts with primary amines in the presence of activators such as EDC or HATU, while the NHS ester also reacts with primary amines, enabling PEGylation and bioconjugation of primary amine-containing molecules.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2639395-41-6
- Formula: C16H25NO10
- Molecular Weight:391.37
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
In Vitro
Acid-PEG4-NHS ester reacts with primary amines through its carboxylic acid group in the presence of activators such as EDC or HATU, while its NHS ester group also reacts with primary amines, enabling PEGylation, bioconjugation, and construction of PROTAC molecules.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2639395-41-6
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Appearance Solid
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Molecular Weight 391.37
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Formula C16H25NO10
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Color White to off-white
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SMILES
O=C(CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (255.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (239 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5551 mL | 12.7756 mL | 25.5513 mL | 63.8782 mL |
| 5 mM | 0.5110 mL | 2.5551 mL | 5.1103 mL | 12.7756 mL | |
| 10 mM | 0.2555 mL | 1.2776 mL | 2.5551 mL | 6.3878 mL | |
| 15 mM | 0.1703 mL | 0.8517 mL | 1.7034 mL | 4.2585 mL | |
| 20 mM | 0.1278 mL | 0.6388 mL | 1.2776 mL | 3.1939 mL | |
| 25 mM | 0.1022 mL | 0.5110 mL | 1.0221 mL | 2.5551 mL | |
| 30 mM | 0.0852 mL | 0.4259 mL | 0.8517 mL | 2.1293 mL | |
| 40 mM | 0.0639 mL | 0.3194 mL | 0.6388 mL | 1.5970 mL | |
| 50 mM | 0.0511 mL | 0.2555 mL | 0.5110 mL | 1.2776 mL | |
| 60 mM | 0.0426 mL | 0.2129 mL | 0.4259 mL | 1.0646 mL | |
| 80 mM | 0.0319 mL | 0.1597 mL | 0.3194 mL | 0.7985 mL | |
| 100 mM | 0.0256 mL | 0.1278 mL | 0.2555 mL | 0.6388 mL |
Acid-PEG4-NHS ester Related Classifications
HY-W800686 Related Classifications
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