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Cat. No.: HY-N9737

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(−)-Acutumine

(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model.

For research use only. We do not sell to patients.

CAS No.: 17088-50-5
Formula: C₁₉H₂₄ClNO₆
Molecular Weight:397.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

(−)-Acutumine Chemical Structure

CAS No.: 17088-50-5

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Fluorescent Dye

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2 2.2.15	CC₅₀	>2.989 mM Compound: 3	Cytotoxicity against human Hep G2.2.15 cells Cytotoxicity against human Hep G2.2.15 cells	[PMID: 17723297]
HepG2 2.2.15	IC₅₀	>2.98 mM Compound: 3	Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion	[PMID: 17723297]
HepG2 2.2.15	IC₅₀	>2.989 mM Compound: 3	Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion	[PMID: 17723297]

Chemical Information

CAS No. 17088-50-5
Molecular Weight 397.85
Formula C₁₉H₂₄ClNO₆
SMILES

COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@@H](C(OC)=CC4=O)O)=C(OC)C3=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Plants
- Menispermaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim CY, et al. The chloroalkaloid (-)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants. Nat Commun. 2020 Apr 20;11(1):1867. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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