country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-106120

Copy Link Print Information

Adolezesin

(Synonyms: Adozelesin; U 73975)

Adolezesin (U 73975) is an analog of CC-1065. Adolezesin is an antineoplastic agent.

For research use only. We do not sell to patients.

CAS No.: 110314-48-2
Formula: C₃₀H₂₂N₄O₄
Molecular Weight:502.52

Storage:

-80°C

Data Sheet (269 KB)

Adolezesin Chemical Structure

CAS No.: 110314-48-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Adolezesin (U 73975) is an analog of CC-1065. Adolezesin is an antineoplastic agent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.0364 ng/mL Compound: 5	Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50% Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50%	[PMID: 10212131]

In Vitro

Adolezesin (U73975; 0-50 pg/mL; 90 min) inhibits ATP contents with IC₅₀s of 0.097, 0.14, 0.36, 0.53 and 1.65 pg/mL against SKUT1B, AN3, AE7, HEC1A and BG1, respectively^[1].
Adolezesin (0-50 pg/mL; 0-168 h) blocks cell cycle at S and G2 phases in SKUT1B cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

SKUT1B
Concentration:

1, 2, 5, 10 and 50 pg/mL
Incubation Time:

0-168 h
Result:

Blocks cell cycle at S and G2 phases at 50 pg/mL in SKUT1B cells.

Chemical Information

CAS No. 110314-48-2
Appearance Solid
Molecular Weight 502.52
Formula C₃₀H₂₂N₄O₄
Color White to light yellow
SMILES

O=C(C1=CC2=CC=CC=C2O1)NC3=CC4=C(NC(C(N5C[C@](C6)([H])[C@]76C8=C(NC=C8C)C(C=C57)=O)=O)=C4)C=C3
Synonyms

Adozelesin; U 73975
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-80°C

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nguyen HN, et al. Spectrum of cell-cycle kinetics of alkylating agent adolezesin in gynecological cancer cell lines: correlation with drug-induced cytotoxicity. J Cancer Res Clin Oncol. 1992;118(7):515-22. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote