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Cat. No.: HY-153640

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AKT-IN-14

AKT-IN-14 (Example 2) is a potent AKTinhibitor with the IC₅₀ values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2781918-35-0
Formula: C₂₂H₂₂BrClF₂N₄OS
Molecular Weight:543.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AKT-IN-14 Chemical Structure

CAS No.: 2781918-35-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

AKT-IN-14 (Example 2) is a potent AKTinhibitor with the IC₅₀ values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 can be used in cancer research^[1].

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
N2a	IC₅₀	<0.63 μM Compound: B6	Antiproliferative activity against mouse Neuro2a cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against mouse Neuro2a cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 37749892]

Chemical Information

CAS No. 2781918-35-0
Molecular Weight 543.86
Formula C₂₂H₂₂BrClF₂N₄OS
SMILES

BrC1=C2C3=C(CCCN2N=C1)SC(C(N[C@H]4[C@H](C5=CC(F)=C(C=C5)F)CCNC4)=O)=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pyrazoloazepine akt inhibitor. WO2022121788A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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