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Cat. No.: HY-184383

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α-Amylase/α-Glucosidase-IN-25

α-Amylase/α-Glucosidase-IN-25 is a α-Amylase inhibitor and a competitive α-Glucosidase inhibitor, with an IC₅₀ of 10.89 μM against α-glucosidase and an IC₅₀ of 20.62 μM against α-amylase. α-Amylase/α-Glucosidase-IN-25 limits carbohydrate digestion. α-Amylase/α-Glucosidase-IN-25 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₂N₂O₄S
Molecular Weight:482.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Amylase/α-Glucosidase-IN-25 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

α‑glucosidase

10.89 μM (IC₅₀)

α-amylase

20.62 μM (IC₅₀)

In Vitro

α-Amylase/α-Glucosidase-IN-25 (Compound 5IT (e)) potently inhibits purified α-amylase with an IC₅₀ of 20.62 μM^[1].
As a competitive inhibitor, α-Amylase/α-Glucosidase-IN-25 potently inhibits purified α-glucosidase, with an IC₅₀ of 10.89 μM and a K_i of 18.8 μM, exhibiting better efficacy than the reference agent Acarbose (HY-B0089)^[1].
α-Amylase/α-Glucosidase-IN-25 (0-25 μM; 24 h) shows no significant cytotoxicity against HEK-293 cells, with a cell viability rate of 90% at the concentration of 25 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK-293 human embryonic kidney cells
Concentration:

0-25 μM
Incubation Time:

24 h
Result:

Showed no significant cytotoxicity up to 25 μM.
Maintained 90% cell viability at 25 μM, indicating safety and biocompatibility within this dose range.

Chemical Information

Molecular Weight 482.55
Formula C₂₈H₂₂N₂O₄S
SMILES

O=C(N(CC(C1=CC=C(OC)C=C1)=O)C/2=O)SC2=C/C3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sruthi K, et al. 2,4-thiazolidinediones as dual-target inhibitors against carbohydrate metabolism enzymes in type 2 diabetes. Bioorganic chemistry. 2026 Jun 09;180:110083. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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