2. Metabolic Enzyme/Protease
  3. Glycosidase Amylases
  4. α-Amylase/α-Glucosidase-IN-25

α-Amylase/α-Glucosidase-IN-25 is a α-Amylase inhibitor and a competitive α-Glucosidase inhibitor, with an IC50 of 10.89 μM against α-glucosidase and an IC50 of 20.62 μM against α-amylase. α-Amylase/α-Glucosidase-IN-25 limits carbohydrate digestion. α-Amylase/α-Glucosidase-IN-25 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

α-Amylase/α-Glucosidase-IN-25

α-Amylase/α-Glucosidase-IN-25 Chemical Structure

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α-Amylase/α-Glucosidase-IN-25 Related Antibodies

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Description

α-Amylase/α-Glucosidase-IN-25 is a α-Amylase inhibitor and a competitive α-Glucosidase inhibitor, with an IC50 of 10.89 μM against α-glucosidase and an IC50 of 20.62 μM against α-amylase. α-Amylase/α-Glucosidase-IN-25 limits carbohydrate digestion. α-Amylase/α-Glucosidase-IN-25 can be used in the research of type 2 diabetes[1].

IC50 & Target[1]

α‑glucosidase

10.89 μM (IC50)

α-amylase

20.62 μM (IC50)

In Vitro

α-Amylase/α-Glucosidase-IN-25 (Compound 5IT (e)) potently inhibits purified α-amylase with an IC50 of 20.62 μM[1].
As a competitive inhibitor, α-Amylase/α-Glucosidase-IN-25 potently inhibits purified α-glucosidase, with an IC50 of 10.89 μM and a Ki of 18.8 μM, exhibiting better efficacy than the reference agent Acarbose (HY-B0089)[1].
α-Amylase/α-Glucosidase-IN-25 (0-25 μM; 24 h) shows no significant cytotoxicity against HEK-293 cells, with a cell viability rate of 90% at the concentration of 25 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Amylase/α-Glucosidase-IN-25 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293 human embryonic kidney cells
Concentration: 0-25 μM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity up to 25 μM.
Maintained 90% cell viability at 25 μM, indicating safety and biocompatibility within this dose range.
Molecular Weight

482.55

Formula

C28H22N2O4S
SMILES

O=C(N(CC(C1=CC=C(OC)C=C1)=O)C/2=O)SC2=C/C3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Amylase/α-Glucosidase-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Amylase/α-Glucosidase-IN-25GlycosidaseAmylaseshuman α-glucosidaseα-amylasecompetitive inhibitorHEK-293 cellshuman α-amylaseactive sitecarbohydrate digestionα-glucosidasegastrointestinal absorptiontype 2 diabetes mellitusInhibitorinhibitorinhibit

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Product Name:
α-Amylase/α-Glucosidase-IN-25
Cat. No.:
HY-184383
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