Altersolanol A
Altersolanol A (Stemphylin; NSC 173943) exhibits antimicrobial activities against Bacillus subtilis and Pseudomonas aeruginosa, with MIC of 25-100 μg/mL. Altersolanol A exhibits no phytotoxicity to Taxus (at dose of 4 μg/μL).
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- CAS No.: 22268-16-2
- 화학식: C16H16O8
- 분자량:336.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
>2 μM
Compound: A
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Antiproliferative activity against human A549 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis
Antiproliferative activity against human A549 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis
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[PMID: 23664494] |
| A549 | EC50 |
29.5 μM
Compound: A
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Cytotoxicity against human A549 cells after 24 hrs by XTT assay
Cytotoxicity against human A549 cells after 24 hrs by XTT assay
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[PMID: 23664494] |
| A549 | IC50 |
>10 μM
Compound: 8
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Cytotoxic activity against human A549 cells by MTT assay
Cytotoxic activity against human A549 cells by MTT assay
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[PMID: 25136754] |
| B16-F10 | IC50 |
>10 μM
Compound: 8
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Cytotoxic activity against mouse B16F10 cells by MTT assay
Cytotoxic activity against mouse B16F10 cells by MTT assay
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[PMID: 25136754] |
| K562 | EC50 |
>1 μM
Compound: A
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Antiproliferative activity against human K562 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis
Antiproliferative activity against human K562 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis
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[PMID: 23664494] |
| K562 | EC50 |
2.5 μM
Compound: A
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Cytotoxicity against human K562 cells after 48 hrs by trypan blue exclusion test
Cytotoxicity against human K562 cells after 48 hrs by trypan blue exclusion test
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[PMID: 23664494] |
| K562 | EC50 |
4 μM
Compound: A
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Cytotoxicity against human K562 cells after 24 hrs by trypan blue exclusion test
Cytotoxicity against human K562 cells after 24 hrs by trypan blue exclusion test
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[PMID: 23664494] |
| K562 | IC50 |
0.8 μM
Compound: A
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Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay
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[PMID: 23664494] |
| K562 | IC50 |
0.8 μM
Compound: Altersolanol A
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Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay
Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay
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[PMID: 24775915] |
| PBMC | EC50 |
4.2 μM
Compound: A
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Effect on metabolism of human PBMCs after 24 hrs by CellTiter-Glo luminescent cell viability assay
Effect on metabolism of human PBMCs after 24 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 23664494] |
Chemical Information
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CAS No. 22268-16-2
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분자량 336.29
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화학식 C16H16O8
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SMILES
O=C1C2=C(C(O)=CC(OC)=C2)C(C3=C1[C@@H](O)[C@](C)(O)[C@H](O)[C@H]3O)=O
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Synonyms
Stemphylin; NSC 173943
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Altersolanol A Related Classifications
HY-125461 Related Classifications
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