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Cat. No.: HY-125461

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Altersolanol A

(Synonyms: Stemphylin; NSC 173943)

Altersolanol A (Stemphylin; NSC 173943) exhibits antimicrobial activities against Bacillus subtilis and Pseudomonas aeruginosa, with MIC of 25-100 μg/mL. Altersolanol A exhibits no phytotoxicity to Taxus (at dose of 4 μg/μL).

For research use only. We do not sell to patients.

CAS No.: 22268-16-2
Formula: C₁₆H₁₆O₈
Molecular Weight:336.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Altersolanol A Chemical Structure

CAS No.: 22268-16-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	>2 μM Compound: A	Antiproliferative activity against human A549 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis Antiproliferative activity against human A549 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis	[PMID: 23664494]
A549	EC₅₀	29.5 μM Compound: A	Cytotoxicity against human A549 cells after 24 hrs by XTT assay Cytotoxicity against human A549 cells after 24 hrs by XTT assay	[PMID: 23664494]
A549	IC₅₀	>10 μM Compound: 8	Cytotoxic activity against human A549 cells by MTT assay Cytotoxic activity against human A549 cells by MTT assay	[PMID: 25136754]
B16-F10	IC₅₀	>10 μM Compound: 8	Cytotoxic activity against mouse B16F10 cells by MTT assay Cytotoxic activity against mouse B16F10 cells by MTT assay	[PMID: 25136754]
K562	EC₅₀	>1 μM Compound: A	Antiproliferative activity against human K562 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis Antiproliferative activity against human K562 cells measured at 6 hrs over 120 hrs by videomicroscopy analysis	[PMID: 23664494]
K562	EC₅₀	2.5 μM Compound: A	Cytotoxicity against human K562 cells after 48 hrs by trypan blue exclusion test Cytotoxicity against human K562 cells after 48 hrs by trypan blue exclusion test	[PMID: 23664494]
K562	EC₅₀	4 μM Compound: A	Cytotoxicity against human K562 cells after 24 hrs by trypan blue exclusion test Cytotoxicity against human K562 cells after 24 hrs by trypan blue exclusion test	[PMID: 23664494]
K562	IC₅₀	0.8 μM Compound: A	Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay	[PMID: 23664494]
K562	IC₅₀	0.8 μM Compound: Altersolanol A	Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay Inhibition of NF-kappaB transactivation in TNF-alpha-stimulated human K562 cells preincubated for 2 hrs followed by TNF-alpha challenge measured after 6 hrs by dual luciferase reporter gene assay	[PMID: 24775915]
PBMC	EC₅₀	4.2 μM Compound: A	Effect on metabolism of human PBMCs after 24 hrs by CellTiter-Glo luminescent cell viability assay Effect on metabolism of human PBMCs after 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 23664494]

Chemical Information

CAS No. 22268-16-2
Molecular Weight 336.29
Formula C₁₆H₁₆O₈
SMILES

O=C1C2=C(C(O)=CC(OC)=C2)C(C3=C1[C@@H](O)[C@](C)(O)[C@H](O)[C@H]3O)=O
Synonyms

Stemphylin; NSC 173943
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang X, et al., A fungal endophyte-tree relationship: Phoma sp. in Taxus wallachiana[J]. Plant Science, 1994, 102(1): 1-9.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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