Amine-PEG3-Lys(PEG3-N3)-PEG3-N3

Art. -Nr.: HY-153672 Reinheit: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (compound 5) is a branched linker that can be used in the synthesis of antibody-drug conjugates (ADCs).

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Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 Chemische Struktur

CAS. Nr. : 2244602-35-3

Größe	Verfügbarkeit	Menge
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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500 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle ADC Linker Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biologische Aktivität
Reinheit & Dokumentation
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Kundenbewertung

Beschreibung

Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (compound 5) is a branched linker that can be used in the synthesis of antibody-drug conjugates (ADCs)^[1].

Molekulargewicht

750.84

Formel

C₃₀H₅₈N₁₀O₁₂

CAS. Nr.

2244602-35-3

Appearance

Oil

Color

Yellow to brown

SMILES

O=C(NCCOCCOCCOCCN=[N+]=[N-])[C@H](CCCCNC(COCCOCCOCCN=[N+]=[N-])=O)NC(COCCOCCOCCN)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (133.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3318 mL	6.6592 mL	13.3184 mL
5 mM	0.2664 mL	1.3318 mL	2.6637 mL
10 mM	0.1332 mL	0.6659 mL	1.3318 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.0%

Select Batch:

Data Sheet (265 KB) SDS (254 KB)

COA (243 KB) HNMR (322 KB) MS (230 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Anami Y, et, al. Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency. Org Biomol Chem. 2017 Jul 5;15(26):5635-5642. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3318 mL	6.6592 mL	13.3184 mL	33.2960 mL
	5 mM	0.2664 mL	1.3318 mL	2.6637 mL	6.6592 mL
	10 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3296 mL
	15 mM	0.0888 mL	0.4439 mL	0.8879 mL	2.2197 mL
	20 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6648 mL
	25 mM	0.0533 mL	0.2664 mL	0.5327 mL	1.3318 mL
	30 mM	0.0444 mL	0.2220 mL	0.4439 mL	1.1099 mL
	40 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8324 mL
	50 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6659 mL
	60 mM	0.0222 mL	0.1110 mL	0.2220 mL	0.5549 mL
	80 mM	0.0166 mL	0.0832 mL	0.1665 mL	0.4162 mL
	100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.3330 mL