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Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

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Based on 5 publication(s) in Google Scholar

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3).

For research use only. We do not sell to patients.

  • Purity: 99.39%
  • Molecular Weight:150 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Experimental Validation Results for Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Chemical Structure
    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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  • 1/16

    Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC50 for this effect is 12.87 ng/mL.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

    Customer Validation
     Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). Quantification and qualification of urine protein.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Jan;22(1):83-96. [Abstract]

    Customer Validation
     Schematic diagram of the application of 4-OHT to the ears of HO (Ppargfl/fl;Krt5creERT2/+) mice for 5 consecutive days, along with intradermal injections of neutralizing antibodies to IFNAR (HY-P99137; Anti-Mouse IFNAR1 Antibody (MAR1-5A3)) or anti-mouse IgG1 isotype controls (HY-P99977; Mouse IgG1 kappa, Isotype Control) on days 3 and 7 (intradermally administered 40 μl of a 2 mg/ml solution). The levels of anti-double-stranded DNA antibodies and antinuclear antibodies in the peripheral blood of the mice on day 17.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

    Customer Validation
     The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative image of heart and wheat germ agglutinin (WGA) staining and quantification of WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

    Customer Validation
     The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative hematoxylin and eosin (H&E) staining and Masson’s trichrome staining showing heart size, cardiomyocyte size, and fibrosis in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

    Customer Validation
     The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Quantification left ventricular end-diastolic anterior wall thickness (LVAW;d), left ventricular end-diastolic posterior wall thickness (LVPW;d), Ejection fraction (EF), Fractional shortening (FS) or left ventricular (LV) mass.

  • 1/16

    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 1;16(1):3140. [Abstract]

    Customer Validation
     The experiment was conducted in C57BL6/N mice with antagonists and antibodies (Anti-Mouse IFNAR1 Antibody (MAR1-5A3); ip; 250 μg/mouse dissolved in saline once daily for 4 weeks beginning with Ang II injection). Representative M-mode echocardiograms of the left ventricle in WT with AngII, MT with AngII, MT with AngII and C-176, and MT with AngII and anti-IFNAR groups.

  • Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Chemical Structure
    1/16
  • Anti-Mouse IFNAR1 Antibody (MAR1-5A3)
  • Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC50 for this effect is 12.87 ng/mL.