Antibacterial agent 370
Antibacterial agent 370 is an inhibitor of mitochondrial complex III (mitochondrial complex III). Antibacterial agent 370 binds to target proteins through hydrogen bonds and Pi-alkyl interactions, disrupts respiration and ATP synthesis, and inhibits the growth of multiple plant pathogenic fungi (fungal). Antibacterial agent 370 can be used in the research of apple tree canker, apple fruit rot, and other plant pathogenic fungal infections.
For research use only. We do not sell to patients.
- Formula: C18H15ClN2O3
- Molecular Weight:342.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antibacterial agent 370 (compound A3) at 20 mg/L exerts potent inhibitory effects on the mycelial growth of Sclerotinia sclerotiorum, Valsa mali, Botrytis cinerea, Rhizoctonia solani, Botryosphaeria dothidea and Fusarium graminearum, with EC50 values of 2.60, 0.577, 3.78, 3.71, 2.46 and 5.22 mg/L, respectively[1].
Antibacterial agent 370 (5 mg/L) disrupts the mycelial structure of Valsa mali and induces surface collapse, distortion, and dehydration phenomena in the mycelia[1].
Antibacterial agent 370 (1-10 mg/L) inhibits the activity of mitochondrial complex III in Valsa mali, with an inhibition rate of 68.9% at 10 mg/L and 42.8% at 5 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antibacterial agent 370 (75-150 mg/L; spray application; 1 time) exhibits a control efficacy of 66.7% against Physalospora piricola on apple fruits at a concentration of 150 mg/L, and a control efficacy of 39.6% at a concentration of 75 mg/L[1].
Antibacterial agent 370 (400-600 mg/L; spray application; 1 time) is safe for two-year-old 'Ruixue' apple seedlings at doses up to 600 mg/L, and no phytotoxicity is observed within 7 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified cultivar (detached branches)[1]
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Dosage:75 mg/L; 150 mg/L
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Administration:sprayed; once
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Result:Produced a mean lesion diameter of 0.5 cm and 100% control efficacy at 150 mg/L.
Produced a mean lesion diameter of 0.8 cm and 84.8% control efficacy at 75 mg/L.
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Animal Model:unspecified cultivar (fruits)[1]
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Dosage:75 mg/L; 150 mg/L
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Administration:sprayed; once
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Result:Produced a mean lesion diameter of 2.1 cm and 66.7% control efficacy at 150 mg/L.
Produced a mean lesion diameter of 3.4 cm and 39.6% control efficacy at 75 mg/L.
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Animal Model:'Ruixue' (two-year-old seedlings)[1]
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Dosage:400 mg/L; 600 mg/L
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Administration:sprayed; once
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Result:Showed no phytotoxic symptoms on 'Ruixue' apple seedlings at 400 mg/L over the 7-day observation period, with normal leaf and new shoot growth.
Showed no phytotoxic symptoms on 'Ruixue' apple seedlings at 600 mg/L over the 7-day observation period, with normal leaf and new shoot growth.
Chemical Information
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Molecular Weight 342.78
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Formula C18H15ClN2O3
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SMILES
ClC1=CC(C2=CC=C(NC=C3C/C(C(OC)=O)=N\O)C3=C2)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 370 Related Classifications
HY-189000 Related Classifications
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Keywords
- Antibacterial agent 370
- Antibacterial agent370
- Antibacterial agent-370
- Fungal
- Mitochondrial Metabolism
- Fusarium graminearum
- mitochondrial complex III
- cytochrome bc complex
- apple fruit rot
- Sclerotinia sclerotiorum
- Valsa mali
- Rhizoctonia solani
- apple valsa canker
- Physalospora piricola
- Botrytis cinerea
- Inhibitor
- inhibitor
- inhibit