Antibacterial agent 89
Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription.
For research use only. We do not sell to patients.
- CAS No.: 2589639-87-0
- Formula: C21H10Cl2F3NO5S
- Molecular Weight:516.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
18.4 nM
Compound: 8e
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Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay
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[PMID: 32920341] |
| HepG2 | CC50 |
387 μM
Compound: 8e
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Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay
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[PMID: 32920341] |
In Vitro
Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 µg/mL, respectively[1].
Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 µg/mL[1].
Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027[1].
Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 µM[1].
Antibacterial agent 89 (1, 2, 4 µg/mL; B. subtilis) alters the localization of bacterial transcription complexes[1].
Antibacterial agent 89 (0.5, 0.25 µg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:S. aureus ATCC 29213 cells
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Concentration:0.5, 0.25 µg/mL
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Incubation Time:
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Result:Reduced the total levels of protein observed in S. aureus ATCC 29213 cells.
Chemical Information
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CAS No. 2589639-87-0
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Molecular Weight 516.27
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Formula C21H10Cl2F3NO5S
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SMILES
O=C(C1=CC=C(C=C1C(C2=CC([N+]([O-])=O)=C(C=C2)SC3=CC(Cl)=C(C=C3)Cl)=O)C(F)(F)F)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 89 Related Classifications
HY-146722 Related Classifications
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