alpha Actinin Antibody(YA3561)
(Synonyms: actinin 1 smooth muscle; actinin alpha 1; ACTN 1; FLJ40884)alpha Actinin Antibody(YA3561) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Actinin.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:50-1:100 | 1:50-1:500 | 1:50-1:100 |
Product Details
alpha Actinin Antibody(YA3561) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Actinin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 103 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 103 kDa；
Recombinant protein within Human ACTN1 aa 388-619 / 892.
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
alpha Actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation[1].
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Subcellular Localization
Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, Z line; Cell membrane; Cell junction; Cell projection, ruffle
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Isoforms & Post-Translational Modification
P12814 has 4 isomers: P12814-1: 103058 Da (predicted); P12814-2: 102709 Da (predicted); P12814-3: 105569 Da (predicted); P12814-4: 107141 Da (predicted).
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Subunit
Homodimer; antiparallel. Interacts with MYOZ2, TTID and LPP (PubMed:10369880, PubMed:11114196, PubMed:12615977). Interacts with DDN (PubMed:16464232). Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN. Interacts with PDLIM1. Interacts with PDLIM2. Interacts with PDLIM4 (via PDZ domain) (By similarity). Interacts with IGSF8 (PubMed:22689882)
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SwissProt ID
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Synonyms
actinin 1 smooth muscle; actinin alpha 1; ACTN 1; FLJ40884
Documentation
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