ATP2A1/SERCA1 Antibody (YA3519)(PBS only)
(Synonyms: ATP2A; SERCA1)ATP2A1/SERCA1 Antibody (YA3519) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP2A1/SERCA1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human, Mouse, Monkey
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
ATP2A1/SERCA1 Antibody (YA3519) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP2A1/SERCA1.
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Host Mouse
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Species ReactivityHuman, Mouse, Monkey
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 110 kDa
Purified recombinant fragment of human ATP2A1 (AA: 487-631) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATP2A1/SERCA1 is key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction[1].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein; Sarcoplasmic reticulum membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Skeletal muscle, fast-twitch fibers (Type II)
Induction:Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression -
Isoforms & Post-Translational Modification
O14983 has 3 isomers: O14983-1: 110252 Da (predicted); O14983-2: 109283 Da (predicted); O14983-3: 95199 Da (predicted).
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Subunit
Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts with VMP1 (PubMed:28890335)
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SwissProt ID
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Synonyms
ATP2A; SERCA1
Documentation
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