C16orf72 Antibody (YA8498)
(Synonyms: PRO0149)C16orf72 Antibody (YA8498) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C16orf72.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:100-250 | 1:100 |
Product Details
C16orf72 Antibody (YA8498) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C16orf72.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 30.7 kDa
Full length human recombinant protein of human C16orf72 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C16orf72 acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1[1][2].
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Subcellular Localization
Nucleus,Cytoplasm
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Expression
Induction: Induced by specific types of stressors like DNA damage, cellular starvation and proteotoxicity
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Isoforms & Post-Translational Modification
Q14CZ0 has two isomers: Q14CZ0-1: 30926 Da (predicted); Q14CZ0-2: 22651 Da (predicted).
Ubiquitinated by HUWE1 -
Subunit
Homooligomer (PubMed:35776542)
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SwissProt ID
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Synonyms
PRO0149
Documentation
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