CACNA1F Antibody (YA5947)

Cat. No.: HY-P86255: Ficha de datos User Guide for Antibodies
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CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño	Stock	Cantidad
20 μL	Obtener un presupuesto	Estimated Time of Arrival: December 31
50 μL	Obtener un presupuesto	Estimated Time of Arrival: December 31
100 μL	Obtener un presupuesto	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.

Host

Rabbit

Clonality

Monoclonal

Peso molecular

Observed band size: 217 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O60840

Gene ID

778 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-5000
FC 1	100-300

Pureza	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization; Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations

Subcellular Localization：Membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expression in skeletal muscle and retina (PubMed:10873387) . Isoform 4 is expressed in retina (PubMed:27226626)

Isoforms & Post-Translational Modification：O60840 has 6 isomers: O60840-1: 220678 Da (predicted); O60840-2: 219496 Da (predicted); O60840-4: 214033 Da (predicted); O60840-5: 211691 Da (predicted); O60840-6: 218559 Da (predicted); O60840-7: 213810 Da (predicted).

Subunit：Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP4; in a calcium independent manner (By similarity)

Synonyms

CACNA1F; CACNAF1; Voltage-dependent L-type calcium channel subunit alpha-1F ; Voltage-gated calcium channel subunit alpha Cav1.4;

Documentación

User Guide for Antibodies (1077 KB)