CACNA1F Antibody (YA5947)
(Synonyms: CACNA1F; CACNAF1; Voltage-dependent L-type calcium channel subunit alpha-1F ; Voltage-gated calcium channel subunit alpha Cav1.4; )CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC 1
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|---|---|---|
| Dilution Ratio | 1:1000-5000 | 100-300 |
Product Details
CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 217 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CACNA1F is a Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization; Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Voltage-dependent L-type calcium channel activates at more hyperpolarized voltages and exhibits a robust calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarizations
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Subcellular Localization
Membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Expression in skeletal muscle and retina (PubMed:10873387) . Isoform 4 is expressed in retina (PubMed:27226626) -
Isoforms & Post-Translational Modification
O60840 has 6 isomers: O60840-1: 220678 Da (predicted); O60840-2: 219496 Da (predicted); O60840-4: 214033 Da (predicted); O60840-5: 211691 Da (predicted); O60840-6: 218559 Da (predicted); O60840-7: 213810 Da (predicted).
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Subunit
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP4; in a calcium independent manner (By similarity)
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SwissProt ID
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Synonyms
CACNA1F; CACNAF1; Voltage-dependent L-type calcium channel subunit alpha-1F ; Voltage-gated calcium channel subunit alpha Cav1.4;
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