CD122 Antibody (YA3799)(PBS only)
(Synonyms: IL2RB; IL15RB; P70-75)CD122 Antibody (YA3799) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD122.
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Host:
Mouse
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
CD122 Antibody (YA3799) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD122.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 61 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 61 kDa
Purified recombinant fragment of human CD122 (AA: extra 27-240) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta binds IL-2 with intermediate affinity, and increases the proportion of CD4+ T lymphocytes[1]. IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2]. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes[3]. Human IL-2R beta consists of extracellular domain (A27-T240), helical domain (I241-I265), and cytoplasmic domain (N266-V551). Human IL-2R beta shares <60% aa sequence identity with mouse and rats. Mouse IL-2R beta shares 81.01% aa sequence identity with rats. IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways[4]. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation[5].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Subunit
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation
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SwissProt ID
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Synonyms
IL2RB; IL15RB; P70-75
Documentation
References
[1]. Xiujuan Zhou, et al. Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder ( Paralichthys olivaceus). Front Immunol. 2020 Sep 9;11:531785. [Content Brief]
[2]. R N Bamfordm, et al. The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A.1994 May 24;91(11):4940-4. [Content Brief]
[3]. Xiujuan Zhou, et al. Immunological characteristics of Interleukin-2 receptor subunit beta (IL-2Rβ) in flounder (Paralichtlys olivaceus): Implication for IL-2R function. Fish Shellfish Immunol. 2019 Oct;93:641-651. [Content Brief]
[4]. Akira Sakai, et al. The role of tumor-associated macrophages on serum soluble IL-2R levels in B-cell lymphomas. J Clin Exp Hematop. 2014;54(1):49-57. [Content Brief]
[5]. M Allouche, et al. Interleukin 2 receptors. Leuk Res. 1990;14(8):699-703. [Content Brief]
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