CD6 Antibody (YA7022)
(Synonyms: CD_antigen=CD6 antibody; CD6 antibody; CD6 antigen Tp120 antibody; CD6 molecule antibody; CD6_HUMAN antibody; FLJ44171 antibody; OX52 antibody; T cell differentiation antigen CD6 antibody; T-cell differentiation antigen CD6 antibody; T12 antibody)CD6 Antibody (YA7022) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD6.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD6 Antibody (YA7022) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD6.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 71.8kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 71.8kDa
Purified recombinant fragment of human CD6 (AA: 18-199) expressed in E. Coli.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD6 (Cluster of Differentiation 6) is a surface glycoprotein of T cells and a subset of B cells, and belongs to the superfamily of scavenger receptor cysteine-rich (SRCR) glycoproteins. CD166, ALCAM and CD318 are ligands for CD6. CD6 interacts with its ligands and plays a key role in thymocyte development, T cell activation and immune responses. CD6 is structurally similar to CD5. CD6 and CD5 have been regarded as co-stimulatory receptors that amplify T-cell receptor (TCR) -dependent activation. CD6 is an important target for therapy against autoimmune diseases, such as Anti-CD6 monoclonal antibody (mAb) [1][2].
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Subcellular Localization
Cell membrane,Secreted
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Expression
Tissue_Specificity: Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain -
Isoforms & Post-Translational Modification
P30203 has 7 isomers: P30203-1: 71801 Da (predicted); P30203-2: 68297 Da (predicted); P30203-3: 63824 Da (predicted); P30203-4: 64663 Da (predicted); P30203-5: 63552 Da (predicted); P30203-6: 58283 Da (predicted); P30203-7: 60572 Da (predicted).
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues丨Glycosylated -
Subunit
Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185)
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SwissProt ID
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Synonyms
CD_antigen=CD6 antibody; CD6 antibody; CD6 antigen Tp120 antibody; CD6 molecule antibody; CD6_HUMAN antibody; FLJ44171 antibody; OX52 antibody; T cell differentiation antigen CD6 antibody; T-cell differentiation antigen CD6 antibody; T12 antibody
Documentation
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