CD63 Antibody (YA5577)

CD63 Antibody (YA5577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD63.

Predicted band size: 26 kDa;

P08962

967 [NCBI]

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Function：Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Lysosome membrane; Multi-pass membrane protein; Late endosome membrane; Multi-pass membrane protein; Endosome, multivesicular body; Melanosome; Secreted, extracellular exosome; Cell surface

Expression：
Tissue_specificity:Detected in platelets (protein level) . Dysplastic nevi, primary melanoma in the radial growth phase, hematopoietic cells, tissue macrophages.

Isoforms & Post-Translational Modification：P08962 has 3 isomers: P08962-1: 25637 Da (predicted); P08962-2: 23430 Da (predicted); P08962-3: 17271 Da (predicted).
Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro)

Subunit：Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1 (PubMed:16917503, PubMed:24635319). Interacts with CD9. Identified in a complex with CD9 and ITGB3 (PubMed:19640571). Interacts with PMEL (PubMed:21962903). Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes (PubMed:23632027). Interacts with SYT7 (By similarity)

Lysosomal associated membrane protein 3 antibody; CD 63 antibody; CD63 antibody; CD63 antigen; melanoma 1 antigen; antibody; CD63 antigen antibody; CD63 antigen melanoma 1 antigen antibody; CD63 molecule antibody; CD63_HUMAN antibody; gp55 antibody; Granulophysin antibody; LAMP 3 antibody; LAMP-3 antibody; LAMP3 antibody; LIMP antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome associated membrane glycoprotein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; Mast cell antigen AD1 antibody; ME491 antibody; Melanoma 1 antigen antibody; Melanoma associated antigen ME491 antibody; Melanoma associated antigen MLA1 antibody; Melanoma-associated antigen ME491 antibody; MGC72893 antibody; MLA 1 antibody; MLA1 antibody; NGA antibody; Ocular melanoma associated antigen antibody; Ocular melanoma-associated antigen antibody; OMA81H antibody; PTLGP40 antibody; Tetraspanin 30 antibody; Tetraspanin-30 antibody; Tspan 30 antibody; Tspan-30 antibody; TSPAN30 antibody;