CD64 Antibody (YA4712)
(Synonyms: High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD antigen CD64; )CD64 Antibody (YA4712) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD64.
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Host:
Mouse
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:5000-100000 | 1-2μg/Test |
Product Details
CD64 Antibody (YA4712) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD64.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human CD64
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FcγRI (CD64) is a high-affinity receptor for the Fc region of immunoglobulin γ. FcγRI (CD64) is constitutively expressed by monocytes, macrophages, and many myeloid progenitor cells. FcγRI (CD64) plays a role in both innate and adaptive immune responses. FcγRI (CD64) mediates the effector function of IgG on monocytes, thereby triggering antibody-dependent cytotoxicity (ADCC) to kill virus-infected cells.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Monocyte/macrophage specific -
Isoforms & Post-Translational Modification
CD64 has 2 isomers: P12314-1: 42632 Da (predicted); P12314-2: 38795 Da (predicted).
Phosphorylated on serine residues -
Subunit
Interacts with IGHG1. Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN
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SwissProt ID
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Synonyms
High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD antigen CD64;
Documentation
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