CD83 Antibody (YA7292)
(Synonyms: CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15)
Based on 1 Customer Validation
CD83 Antibody (YA7292) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-100 | 1:100-500 |
Product Details
CD83 Antibody (YA7292) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD83.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Human,Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
A synthesized peptide derived from human CD83: 50-95/205.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD83 is a Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections[1].
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Subcellular Localization
Membrane
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Expression
Tissue_Specificity: Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells
Induction: Strongly up-regulated together with costimulatory molecules such as CD80 and CD86 during dendritic cell maturation -
Isoforms & Post-Translational Modification
Q01151: 205 amino acids, molecular weight 23042 Da.
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Subunit
Monomer
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SwissProt ID
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Synonyms
CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15
Documentation
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