CGRP Antibody (YA6505)

Cat. No.: HY-P86812: Data Sheet COA
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CGRP Antibody (YA6505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CGRP.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Verification Image
Background
Documentation

Description

CGRP Antibody (YA6505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CGRP.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 14 kDa;

Observed band size: 10 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P01256

Gene ID

796 [NCBI]

Immunogen

Recombinant protein within rat CGRP aa 1-128.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:10000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:500

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

IHC-P

Immunohistochemical analysis of paraffin-embedded rat colon tissue using CGRP Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
Immunohistochemical analysis of paraffin-embedded rat colon tissue using CGRP Antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 8 minutes. The tissues were blocked in QuickBlock for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody at 1/100 dilution in 4℃ overnight. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Background

Function：CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Expressed in spinal cord

Isoforms & Post-Translational Modification：P06881 has three isomers: P06881-1: 13899 Da (predicted); P01258-1: 15467 Da (predicted); P01258-2: 15535 Da (predicted).

RRID

AB_3719216

Database

SwissProt: P06881 Human ; P10092 Human ; P70160 Mouse ; Q99JA0 Mouse ; P01256 Rat ; P01257 Rat

Synonyms

Calcitonin/calcitonin related polypeptide alpha antibody; Alpha type CGRP antibody; Beta type CGRP antibody; CALC1 antibody; CALC2 antibody; CALCA antibody; CALCB antibody; Calcitonin 1 antibody; Calcitonin 2 antibody; Calcitonin gene related peptide I antibody; Calcitonin/calcitonin related polypeptide alpha antibody; Alpha type CGRP antibody; Beta type CGRP antibody; CALC1 antibody; CALC2 antibody; CALCA antibody; CALCB antibody; Calcitonin 1 antibody; Calcitonin 2 antibody; Calcitonin gene related peptide I antibody; Calcitonin gene related peptide II antibody; Calcitonin related polypeptide alpha antibody; Calcitonin related polypeptide beta antibody; CGRP antibody; CGRP I antibody; CGRP II antibody; CGRP1 antibody; CGRP2 antibody; CT antibody; Katacalcin antibody; KC antibody;

Documentation

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Data Sheet (231 KB) SDS (254 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)