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CNOT7 Antibody (YA6509)

(Synonyms: BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; CNOT 7 antibody; Cnot7 antibody; CNOT7_HUMAN antibody; hCAF 1 antibody; hCAF1 antibody; )
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CNOT7 Antibody (YA6509) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CNOT7.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • CNOT7 Antibody (YA6509) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:2000 1:100 1:1000

Product Details

Description

CNOT7 Antibody (YA6509) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CNOT7.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 33 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 33 kDa
Immunogen

Recombinant protein within human CNOT7 aa 1-285 / 285.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CNOT7 is a Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity[1][2][3][4][5][6].

  • Subcellular Localization

    Nucleus,Cytoplasm, P-body,Cytoplasm, Cytoplasmic ribonucleoprotein granule

  • Isoforms & Post-Translational Modification

    Q9UIV1 has two isomers: Q9UIV1-1: 32745 Da (predicted); Q9UIV1-2: 28228 Da (predicted).

  • Subunit

    Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367)

  • SwissProt ID

    Q9UIV1

  • Gene ID
    29883 [NCBI]
  • Synonyms

    BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; BTG1 binding factor 1 antibody; BTG1-binding factor 1 antibody; CAF 1 antibody; CAF-1 antibody; CAF1 antibody; Carbon catabolite repressor protein (CCR4) associative factor 1 antibody; CCR4 associated factor 1 antibody; CCR4 NOT transcription complex subunit 7 antibody; CCR4-associated factor 1 antibody; CCR4-NOT transcription complex subunit 7 antibody; CNOT 7 antibody; Cnot7 antibody; CNOT7_HUMAN antibody; hCAF 1 antibody; hCAF1 antibody;

CNOT7 Antibody (YA6509) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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