COPS4 Antibody (YA7152)
(Synonyms: CSN4, COPS4, COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4, JAB1-containing signalosome subunit 4)
Based on 1 Customer Validation
COPS4 Antibody (YA7152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to COPS4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-100 |
Product Details
COPS4 Antibody (YA7152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to COPS4.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 46kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 46kDa
A synthesized peptide derived from human COPS4: 5-38.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
COPS4 component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
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Subcellular Localization
Cytoplasm,Nucleus,Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
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Isoforms & Post-Translational Modification
Q9BT78 has two isomers: Q9BT78-1: 46269 Da (predicted); Q9BT78-2: 40197 Da (predicted).
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Subunit
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823)
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SwissProt ID
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Synonyms
CSN4, COPS4, COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4, JAB1-containing signalosome subunit 4
Documentation
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