Cytokeratin 8 Antibody (YA3662)
(Synonyms: CK8; CYK8; K2C8; KRT8)Cytokeratin 8 Antibody (YA3662) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 8.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
Cytokeratin 8 Antibody (YA3662) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 8.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 54 kDa
Purified recombinant fragment of human Cytokeratin (aa391-483) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cytokeratin 8 is a Cytokeratin 8 together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle
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Subcellular Localization
Cytoplasm; Nucleus, nucleoplasm; Nucleus matrix
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Expression
Tissue_specificity:Aggregates of dystrophin and actin are observed in muscle fibers at the sarcoplasmic sarcomere and sarcomere. They are also expressed in the gingival mucosa and hard palate of the oral cavity. -
Isoforms & Post-Translational Modification
Cytokeratin 8 has 2 isomers: P05787-1: 53704 Da (predicted); P05787-2: 56608 Da (predicted).
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization;O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation;O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner -
Subunit
Heterotetramer of two type I and two type II keratins. Forms a heterodimer with KRT18. Associates with KRT20. Interacts with PLEC isoform 1C, when in a heterodimer with KRT18. Interacts with PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Interacts with GPER1. Interacts with EPPK1 (By similarity). Interacts with PKP1 and PKP2
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SwissProt ID
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Synonyms
CK8; CYK8; K2C8; KRT8
Documentation
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