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Cat. No.: HY-P82634A

Desmoplakin Antibody (YA2379)(PBS only)

Name: Desmoplakin Antibody (YA2379)(PBS only)
Brand: MedChemExpress
SKU: HY-P82634A
Availability: PreOrder

(Synonyms: Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2)

Desmoplakin Antibody (YA2379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoplakin.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry
Dilution Ratio	1:1000-1:5000	1:500-1:1000	1:100-1:200

Description

Desmoplakin Antibody (YA2379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoplakin.

Host Rabbit
Species Reactivity
Human, Rat
Observed Molecular Weight

Observed band size: 270 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 332 kDa

Immunogen

A synthesized peptide derived from human Desmoplakin

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Desmoplakin is a Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance
Subcellular Localization

Cell junction, desmosome; Cell membrane; Cytoplasm
Expression

Tissue_specificity:Expressed in oral mucosa (at protein level) (PubMed:30479852) . Expressed in arrector pili muscle (at protein level) (PubMed:29034528) . Expressed in the heart in the heart (at protein level) (PubMed:18662195) ; Apparently an obligate constituent of all desmosomes; Resides predominantly in tissues and cells of stratified origin
Isoforms & Post-Translational Modification

P15924 has 3 isomers: P15924-1: 331774 Da (predicted); P15924-2: 260119 Da (predicted); P15924-3: 278916 Da (predicted).
Phosphorylation at Ser-2849 increases association with intermediate filament cytokeratin, potentially facilitating interaction between desmosome junctions and intermediate filament architecture
Subunit

Homodimer. Interacts with COL17A1 (via cytoplasmic region) (PubMed:12482924). Interacts with DSC2 (PubMed:21062920). Interacts with PKP2 (PubMed:11790773, PubMed:22781308). Interacts with PKP1 (PubMed:10852826, PubMed:11790773, PubMed:23444369). Interacts weakly with TMEM65
SwissProt ID

P15924
Gene ID

1832 [NCBI]
Synonyms

Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2
Research Field

Signal Transduction