DRD2 Antibody (YA8862)
(Synonyms: CD54, Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, ICAM1)
Based on 1 Customer Validation
DRD2 Antibody (YA7708) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DRD2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-F, ICC/IF, FC
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:10000 | 1:500 | 1:100 | 1:1000 |
Product Details
DRD2 Antibody (YA7708) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DRD2.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 51 kDa
Recombinant protein within human Dopamine D2 Receptor aa 214-373.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DRD2 is a Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1[1][2][3][4][5][6].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithelial cells, certain other epithelial cells, and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic cells in tonsils, lymph nodes, and Peyer's patches. Expressed in low amounts on peripheral blood leukocytes.
Induction: Up-regulated by coagulation factor Xa (F10) in atrial tissues. Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation. Induced by either inflammatory cytokines. -
Isoforms & Post-Translational Modification
DRD2 has an amino acid length of 532, molecular weight is 57825 Da.
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis -
Subunit
Homodimer.
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SwissProt ID
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Synonyms
CD54, Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, ICAM1
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Research Field
Immunology
Documentation
[1]. Dustin ML, et al. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 1;137(1):245-54. [Content Brief]
[2]. Simmons D, et al. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature. 1988 Feb 18;331(6157):624-7. [Content Brief]
[3]. Lacouture C, et al. LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity. Nat Commun. 2024 Jan 9;15(1):407. [Content Brief]
[4]. Diamond MS, et al. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol. 1990 Dec;111(6 Pt 2):3129-39. [Content Brief]
[5]. van Buul JD, et al. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol. 2007 Sep 24;178(7):1279-93. [Content Brief]
[6]. Hayashi T, et al. MUC1 mucin core protein binds to the domain 1 of ICAM-1. Digestion. 2001;63 Suppl 1:87-92. [Content Brief]
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