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DTNB (Dystrobrevin beta) Antibody (YA8321)

(Synonyms: MGC17163; MGC57126)
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DTNB (Dystrobrevin beta) Antibody (YA8321) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DTNB (Dystrobrevin beta).

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • DTNB (Dystrobrevin beta) Antibody (YA8321) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:2000 1:150-500 1:100-250 1:100

Product Details

Description

DTNB (Dystrobrevin beta) Antibody (YA8321) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DTNB (Dystrobrevin beta).

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 63.6 kDa
Immunogen

Full length human recombinant protein of human DTNB produced in HEK293T cell.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DTNB is a Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses[1].

  • Subcellular Localization

    Cytoplasm,Postsynaptic density,Cell projection, dendrite,Basal cell membrane,Postsynapse,Nucleus

  • Expression


    Tissue_Specificity: Highly expressed in brain, kidney and pancreas
    Induction: Post-transcriptionally repressed by microRNA miR-143 during neural differentiation

  • Isoforms & Post-Translational Modification

    O60941 has 7 isomers: O60941-1: 71356 Da (predicted); O60941-2: 64603 Da (predicted); O60941-3: 64424 Da (predicted); O60941-4: 68061 Da (predicted); O60941-5: 63760 Da (predicted); O60941-6: 61538 Da (predicted); O60941-7: 69294 Da (predicted).
    Phosphorylated by PKA

  • Subunit

    Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (PubMed:10747910)

  • SwissProt ID

    O60941

  • Synonyms

    MGC17163; MGC57126

DTNB (Dystrobrevin beta) Antibody (YA8321) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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