DYNC1LI1 Antibody (YA7831)(PBS only)
(Synonyms: DLC-A; DNCLI1; LIC1)DYNC1LI1 Antibody (YA7831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DYNC1LI1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-250 | 1:100 |
Product Details
DYNC1LI1 Antibody (YA7831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DYNC1LI1.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 56.4 kDa
Full length human recombinant protein of human DYNC1LI1 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DYNC1LI1 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC)[1].
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Subcellular Localization
Cytoplasm,Chromosome, centromere, kinetochore,Cytoplasm, cytoskeleton, spindle pole,Recycling endosome membrane
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Isoforms & Post-Translational Modification
Q9Y6G9: 523 amino acids, molecular weight 56579 Da.
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Subunit
Homodimer (By similarity)
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SwissProt ID
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Synonyms
DLC-A; DNCLI1; LIC1
Documentation
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