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EDN1 Antibody (YA3655)(PBS only)

(Synonyms: ET1; QME; PPET1; ARCND3; HDLCQ7)

EDN1 Antibody (YA3655) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to EDN1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    ICC/IF, FC, ELISA

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • EDN1 Antibody (YA3655)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

EDN1 Antibody (YA3655) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to EDN1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 24 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 24.4 kDa
Immunogen

Purified recombinant fragment of human EDN1 (AA: 18-212) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    EDN1 is an Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2[1][2].

  • Subcellular Localization

    Secreted

  • Expression


    Tissue_specificity:Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells

  • SwissProt ID

    P05305

  • Gene ID
    1906 [NCBI]
  • Synonyms

    ET1; QME; PPET1; ARCND3; HDLCQ7

EDN1 Antibody (YA3655)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • EDN1 Antibody (YA3655)(PBS only) Product Image
    1/16
  • EDN1 Antibody (YA3655)(PBS only) Product Image