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EMG1 Antibody (YA8490)(PBS only)

(Synonyms: C2F; Grcc2f; NEP1)

EMG1 Antibody (YA8490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EMG1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    ICC/IF, FC

  • Reactivity :

    Human, Dog, Monkey, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • EMG1 Antibody (YA8490)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100-250 1:100

Product Details

Description

EMG1 Antibody (YA8490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to EMG1.

  • Host Mouse
  • Species Reactivity
    Human, Dog, Monkey, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 26.5 kDa
Immunogen

Full length human recombinant protein of human EMG1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    EMG1 is a S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome[1][2].

  • Subcellular Localization

    Nucleus, nucleolus

  • Isoforms & Post-Translational Modification

    Q92979: 244 amino acids, molecular weight 26720 Da.

  • Subunit

    Homodimer

  • SwissProt ID

    Q92979

  • Synonyms

    C2F; Grcc2f; NEP1

EMG1 Antibody (YA8490)(PBS only) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • EMG1 Antibody (YA8490)(PBS only) Product Image
    1/16
  • EMG1 Antibody (YA8490)(PBS only) Product Image