FIP200 Antibody (YA6986)

Cat. No.: HY-P87303: Ficha de datos COA
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FIP200 Antibody (YA6986) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FIP200.

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Tamaño	Stock	Cantidad
20 μL	En stock	Estimated Time of Arrival: December 31
50 μL	En stock	Estimated Time of Arrival: December 31
100 μL	En stock	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

FIP200 Antibody (YA6986) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FIP200.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 183 kDa;

Observed band size: 250/150 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8TDY2

Immunogen

Recombinant protein within Human RB1CC1 aa 651-800 / 1,594.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200
FC FC: Flow Cytometry	1:1000

Sensitivity	Endogenous	Pureza	Immunogen affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity)

Subcellular Localization：Nucleus,Cytoplasm,Cytoplasm, cytosol,Preautophagosomal structure,Lysosome

Expression：
Tissue_Specificity: Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells

Isoforms & Post-Translational Modification：Q8TDY2 has two isomers: Q8TDY2-1: 183091 Da (predicted); Q8TDY2-2: 182848 Da (predicted).
Phosphorylation at Ser-734 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB

Subunit：Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1 (PubMed:19211835, PubMed:19597335)

Synonyms

FAK family kinase-interacting protein of 200 kDa antibody; FIP200 antibody; RB1-inducible coiled-coil protein 1 antibody; RB1CC1 antibody; RBCC1_HUMAN antibody

Documentación

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Ficha de datos (231 KB) SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)