Copy Link Print Information

FKBP38 Antibody (YA2803)

(Synonyms: FKBP 38; Fkbp8; FKBPR38; hFKBP38; Rotamase; Sam11)
Customer Review

Based on 1 Customer Validation

FKBP38 Antibody (YA2803) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP38.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for FKBP38 Antibody (YA2803)
  • FKBP38 Antibody (YA2803) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-1:1000 1:50-1:200 1:50-1:100

Product Details

Description

FKBP38 Antibody (YA2803) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP38.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 52 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 45 kDa
Species Reactivity Database

Entrez Gene: 23770 Human

SwissProt: Q14318 Human

Immunogen

A synthesized peptide derived from human FKBP38 aa1-46/412.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105174

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for FKBP38 Antibody (YA2803)
    Western blot analysis was performed on extracts from HeLa (lane 1, 15 μg), 293T (lane 2, 15 μg), Jurkat (lane 3, 15 μg), 293 (lane 4, 15 μg), and HepG2 (lane 5, 15 μg) using FKBP38 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:20000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background

  • Function

    FKBP38 is a Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV)[1].

  • Subcellular Localization

    Mitochondrion; Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side; Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side; Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side

  • Expression


    Tissue_specificity:Widely expressed. Highest levels seen in the brain. Highly abundant in the retina

  • Isoforms & Post-Translational Modification

    Q14318 has 3 isomers: Q14318-1: 44562 Da (predicted); Q14318-2: 44649 Da (predicted); Q14318-3: 27545 Da (predicted).
    Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30

  • Subunit

    Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation

  • SwissProt ID

    Q14318

  • Gene ID
    23770 [NCBI]
  • Synonyms

    FKBP 38; Fkbp8; FKBPR38; hFKBP38; Rotamase; Sam11

  • Research Field

    -

FKBP38 Antibody (YA2803) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedchemExpress Validation
     Western blot analysis was performed on extracts from HeLa (lane 1, 15 μg), 293T (lane 2, 15 μg), Jurkat (lane 3, 15 μg), 293 (lane 4, 15 μg), and HepG2 (lane 5, 15 μg) using FKBP38 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:20000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • FKBP38 Antibody (YA2803) Product Image
    1/16
  • Experimental Validation Results for FKBP38 Antibody (YA2803)
  • FKBP38 Antibody (YA2803) Product Image
  • Experimental Validation Results for FKBP38 Antibody (YA2803)
    1/1
    MedchemExpress Validation
     Western blot analysis was performed on extracts from HeLa (lane 1, 15 μg), 293T (lane 2, 15 μg), Jurkat (lane 3, 15 μg), 293 (lane 4, 15 μg), and HepG2 (lane 5, 15 μg) using FKBP38 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:20000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.
  • Experimental Validation Results for FKBP38 Antibody (YA2803)
  • FKBP38 Antibody (YA2803) Product Image
    MedchemExpress Validation

    Western blot analysis was performed on extracts from HeLa (lane 1, 15 μg), 293T (lane 2, 15 μg), Jurkat (lane 3, 15 μg), 293 (lane 4, 15 μg), and HepG2 (lane 5, 15 μg) using FKBP38 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non - fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:20000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti - Rabbit IgG - HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

  • FKBP38 Antibody (YA2803) Product Image WB