FKBP52 Antibody (YA7219)
(Synonyms: FKBP52, FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 59 kDa immunophilin, FK506-binding protein 4, FKBP59, HSP-binding immunophilin, Immunophilin FKBP52, Rotamase, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI)
Based on 1 Customer Validation
FKBP52 Antibody (YA7219) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP52.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 | 1:50-100 | 1:50-200 |
Product Details
FKBP52 Antibody (YA7219) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP52.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 52 kDa;
KLH conjugated synthetic peptide derived from human FKBP52
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FKBP52 is an Hsp90-binding immunophilin and peptidyl-prolyl isomerase that acts as a positive regulator of steroid hormone receptor signaling, especially androgen receptor, glucocorticoid receptor, and progesterone receptor pathways[1][2]. Mechanistically, FKBP52 associates with receptor-Hsp90 complexes, supports hormone binding and receptor localization, and directly binds the folded, ligand-bound glucocorticoid receptor in the GR:Hsp90:FKBP52 complex[2][3]. In prostate cancer models, FKBP52 supports androgen receptor activity, β-catenin interaction with AR, AR dimer formation, chromatin binding, and phosphorylation[4][5][6]. Compared with the related isoform FKBP51, FKBP52 shows functional divergence despite structural similarity, and cryo-EM evidence shows FKBP51 competes with FKBP52 for GR:Hsp90 binding and antagonizes FKBP52-dependent GR activity[2][3]. For experimental applications, MJC13 inhibits FKBP52-regulated AR signaling by preventing hormone-dependent dissociation of the Hsp90-FKBP52-AR complex and by blocking β-catenin interaction with the AR ligand-binding domain[4][5].
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Subcellular Localization
Cytoplasm, cytosol,Mitochondrion,Nucleus,Cytoplasm, cytoskeleton,Cell projection, axon
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
Q02790: 459 amino acids, molecular weight 51805 Da.
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Subunit
Homodimer (By similarity)
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SwissProt ID
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Synonyms
FKBP52, FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 59 kDa immunophilin, FK506-binding protein 4, FKBP59, HSP-binding immunophilin, Immunophilin FKBP52, Rotamase, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI
Documentation
References
[1]. Riggs DL, et al. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003 Mar 3;22(5):1158-67. [Content Brief]
[2]. Storer CL, et al. FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol Metab. 2011 Dec;22(12):481-90. [Content Brief]
[3]. Noddings CM, et al. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat Struct Mol Biol. 2023 Dec;30(12):1867-1877. [Content Brief]
[4]. De Leon JT, et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11878-83. [Content Brief]
[5]. Storer Samaniego C, et al. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015 Jul 24;10(7):e0134015. [Content Brief]
[6]. Maeda K, et al. FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells. Mol Oncol. 2022 Feb;16(4):940-956. [Content Brief]
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