Frizzled 7 Antibody
(Synonyms: FZD1, FZD2, FZD7, Frizzled-7, Fz-7, hFz7, FzE3)
Based on 1 Customer Validation
Frizzled 7 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Frizzled 7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:200-500 | 1:20000 |
Product Details
Frizzled 7 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Frizzled 7.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 63 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 63 kDa
Synthesized peptide derived from human Frizzled 7
Endogenous
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Frizzled 7 is a Wnt protein receptor. Most frizzled protein receptors are coupled to the classical β-catenin signaling pathway, leading to Dishevelled protein activation, GSK-3 kinase inhibition, β-catenin nuclear accumulation, and Wnt target gene activation. Upon ligand activation, Frizzled 7 binds to CCDC88C/DAPLE, displacing DVL1 from FZD7, thereby inhibiting the canonical Wnt signaling pathway. CCDC88C then activates the G protein and triggers the non-canonical Wnt response.
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Subcellular Localization
Cell membrane, Endosome membrane; Multi-pass membrane protein
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Expression
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas. -
Isoforms & Post-Translational Modification
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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Subunit
Interacts with CCDC88C/DAPLE; the interaction displaces DVL1 from FZD7, leading to inhibition of canonical Wnt signaling and triggering of non-canonical Wnt responses. Interacts with MYOC. Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3). Interacts with glypican GPC3.
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SwissProt ID
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Synonyms
FZD1, FZD2, FZD7, Frizzled-7, Fz-7, hFz7, FzE3
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Research Field
Cell Biology
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