FZD7 - frizzled class receptor 7 Gene

Also Known as FzE3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8324

About FZD7

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,033,855-202,038,441 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

FZD7 Products (1)

mRNA	Protein	Name
NM_003507.2	NP_003498.1	frizzled-7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	18256285	GOA
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	18313787	GOA
enables frizzled binding	IPI IPI: Inferred from physical interaction	19188438	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	27386966	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18215320	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18313787	GOA
involved in mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	17016432	GOA
involved in negative regulation of cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	23939491	GOA
involved in negative regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	18156211	GOA
involved in negative regulation of ectodermal cell fate specification	IMP IMP: Inferred from mutant phenotype	18681827	GOA
involved in non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19773752	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18215320	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19773752	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19773752	GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing	IMP IMP: Inferred from mutant phenotype	18313787	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	18256285	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18681827	GOA
involved in regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	9707618	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18681827	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18256285	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	27386966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD7 Protein Structure

Frizzled

0
100
200
300
400
500
574 a.a.

Protein Preferred Names	Protein Names
frizzled-7	Frizzled, drosophila, homolog of, 7

FZD7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FZD7	O75084	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	FZD7	O75084	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	FZD7	O75084	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SLC6A15	Homo sapiens	Q9H2J7	Validated Y2H	32296183
Intra	FZD7	O75084	SLC6A15	Homo sapiens	Q9H2J7	Y2H Array	32296183
Intra	FZD7	O75084	SLC6A15	Homo sapiens	Q9H2J7	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	FZD7	O75084	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	FZD7	O75084	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	FZD7	O75084	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	FZD7	O75084	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	FZD7	O75084	MGST1	Homo sapiens	P10620	Validated Y2H	32296183
Intra	FZD7	O75084	MGST1	Homo sapiens	P10620	Y2H Array	32296183
Intra	FZD7	O75084	MGST1	Homo sapiens	P10620	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	FZD7	O75084	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	FZD7	O75084	WNT3	Homo sapiens	P56703	Pull Down	21314951
Intra	FZD7	O75084	WNT3	Homo sapiens	P56703	Anti Tag CoIP	18313787
Intra	FZD7	O75084	SDCBP	Homo sapiens	O00560	Anti Bait CoIP	18256285
Intra	FZD7	O75084	SDCBP	Homo sapiens	O00560	Far-WB	18256285
Intra	FZD7	O75084	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	FZD7	O75084	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	FZD7	O75084	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	FZD7	O75084	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	FZD7	O75084	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	FZD7	O75084	NCS1	Homo sapiens	P62166	Validated Y2H	32296183
Intra	FZD7	O75084	NCS1	Homo sapiens	P62166	Y2H Array	32296183
Intra	FZD7	O75084	NCS1	Homo sapiens	P62166	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	FZD7	O75084	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	FZD7	O75084	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	FZD7	O75084	HPCAL1	Homo sapiens	P37235	Validated Y2H	32296183
Intra	FZD7	O75084	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	NCALD	Homo sapiens	P61601	Y2H Array	32296183
Intra	FZD7	O75084	NCALD	Homo sapiens	P61601	Validated Y2H	32296183
Intra	FZD7	O75084	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	FZD7	O75084	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	FZD7	O75084	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78730	Frizzled-7 Protein, Human (HEK293, His)	O75084 (Q33-L185)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P79214	Frizzled-7 Protein, Human (CHO, hFc)	O75084/NP_003498 (Q33-L185)	≥ 95%, as determined by reducing SDS-PAGE.

FZD7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810708	Frizzled 7 Antibody	WB, ICC/IF, ELISA	Human, Mouse
HY-P810709	Frizzled 1/2/7 Antibody	WB, ICC/IF	Human, Mouse, Rat, Chicken

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1454	Fz7-21	Antagonist	99.31%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117002	SRI 37892	Inhibitor	99.28%	Unkown
HY-156095	F7H	Inhibitor	99.95%	Unkown
HY-P1454A	Fz7-21 TFA	Antagonist	98.12%	Unkown
HY-P1454B	Fz7-21S		98.91%	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-RS05183	FZD7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17191	Fzd7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23642	Fzd7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26883	Cdk15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FZD7	VGNC	VGNC:99364
Felis catus	FZD7	VGNC	VGNC:80213
Bos taurus	FZD7	VGNC	VGNC:29171
Mus musculus	FZD7	MGD	MGI:108570
Canis familiaris	FZD7	VGNC	VGNC:57384
Rattus norvegicus	FZD7	RGD	RGD:2321905
Others	FZD7	NCBI