GBP5 Antibody (YA8130)(PBS only)
(Synonyms: GBP-5)GBP5 Antibody (YA8130) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GBP5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:100-250 | 1:100 |
Product Details
GBP5 Antibody (YA8130) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GBP5.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 66.4 kDa
Full length human recombinant protein of human GBP5 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GBP5 is an Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins |Antigenic tumor-specific truncated splice form[1][2][3][4].
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Subcellular Localization
Cytoplasmic vesicle membrane,Golgi apparatus membrane,Cytoplasm
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Expression
Tissue_Specificity: Expressed in peripheral blood monocytes (at protein level)
Induction: By IFNG in endothelial cells and in LPS-primed macrophages -
Isoforms & Post-Translational Modification
Q96PP8 has two isomers: Q96PP8-1: 66617 Da (predicted); Q96PP8-2: 55247 Da (predicted).
Isoprenylation is required for proper subcellular location -
Subunit
Homodimer; homodimerizes upon GTP-binding, forming a close face-to-face dimer (PubMed:20180847, PubMed:21151871, PubMed:33876762)
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SwissProt ID
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Synonyms
GBP-5
Documentation
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