GluA4 Antibody (YA9736)
(Synonyms: AMPA 4, AMPA selective glutamate receptor 4, AMPA-selective glutamate receptor 4, AMPA4, GluA 4, GluA4, GluR 4, GluR D, GluR-4, GluR-D)GluA4 Antibody (YA9736) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to GluA4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:500-1000 |
Product Details
GluA4 Antibody (YA9736) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to GluA4.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 101 kDa;
Synthetic peptide of Human GluA4 (aa 853-902).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GluA4 is an Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate[1].
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Subcellular Localization
Cell membrane; Postsynaptic cell membrane; Cell projection, dendrite
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Isoforms & Post-Translational Modification
GluA4 has 2 isoforms, P48058-1: amino acid length is 902, molecular weight is 100871 Da (predicted); P48058-2: amino acid length is 433, molecular weight is 49146 Da (predicted).发生棕榈酰化修饰。L-谷氨酸刺激后发生去棕榈酰化。Cys-611 位点的棕榈酰化会导致高尔基体滞留，降低细胞表面表达量。相反，Cys-837 位点的棕榈酰化不影响细胞表面表达，但会调控刺激依赖性内吞作用GluA4 存在 2 个异构体，P48058-1：氨基酸个数为 902 个，分子量为 100871 Da (预测)；P48058-2：氨基酸个数为 433 个，分子量为 49146 Da (预测)。Palmitoylated. Depalmitoylated upon L-glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis
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Subunit
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits.
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SwissProt ID
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Synonyms
AMPA 4, AMPA selective glutamate receptor 4, AMPA-selective glutamate receptor 4, AMPA4, GluA 4, GluA4, GluR 4, GluR D, GluR-4, GluR-D
Documentation
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