Human CD138 Antibody (PE)(YA3444)
(Synonyms: CD_antigen antibody; CD138 antibody; CD138 antigen antibody; heparan sulfate proteoglycan fibroblast growth factor receptor antibody; SDC antibody; Sdc1 antibody; SDC1_HUMAN antibody; SYND1 antibody; Syndecan 1 antibody; Syndecan antibody; syndecan proteoglycan 1 antibody; Syndecan-1 antibody)Human CD138 Antibody (PE)(YA3444) is a PE-conjugated, mouse-derived and phycoerythrin (PE) IgG1 monoclonal antibody, targeting to CD138.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS、0.5%BSA、0.03%PC-300.
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Conjugation:
PE
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5μL per test for million cells or whole blood in 100 μL volume. |
Product Details
Human CD138 Antibody (PE)(YA3444) is a PE-conjugated, mouse-derived and phycoerythrin (PE) IgG1 monoclonal antibody, targeting to CD138.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
A synthesized peptide derived from Human CD183.
Affinity
PE
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS、0.5%BSA、0.03%PC-300.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
Human CD138 receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling; Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis; Mediates the activity of CXCL11[1].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isomer 1 and isomer 2 are primarily expressed in the heart, kidneys, liver, and skeletal muscle. Isomer 1 is also expressed in the placenta. Isomer 2 is expressed in endothelial cells. It is also expressed in T cells (protein level) . -
Isoforms & Post-Translational Modification
P49682 has 3 isomers: P49682-1: 40660 Da (predicted); P49682-2: 45523 Da (predicted); P49682-3: 28715 Da (predicted).
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction;N-glycosylated -
Subunit
Homomer. Forms heteromers with ACKR4
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SwissProt ID
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Synonyms
CD_antigen antibody; CD138 antibody; CD138 antigen antibody; heparan sulfate proteoglycan fibroblast growth factor receptor antibody; SDC antibody; Sdc1 antibody; SDC1_HUMAN antibody; SYND1 antibody; Syndecan 1 antibody; Syndecan antibody; syndecan proteoglycan 1 antibody; Syndecan-1 antibody
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