IFIT1 Antibody (YA7842)(PBS only)

Cat. No.: HY-P88158A: Ficha de datos User Guide for Antibodies
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IFIT1 Antibody (YA7842) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IFIT1.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

IFIT1 Antibody (YA7842) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IFIT1.

Host

Mouse

Peso molecular

Predicted band size: 55.2 kDa

Species Reactivity

Human

SwissProt ID

P09914

Immunogen

Full length human recombinant protein of human IFIT1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-100
FC FC: Flow Cytometry	1:100

Pureza	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486)

Subcellular Localization：Cytoplasm

Expression：Induction: By type I interferons, dsRNAs and viruses

Isoforms & Post-Translational Modification：P09914 has two isomers: P09914-1: 55360 Da (predicted); P09914-2: 51713 Da (predicted).
Phosphorylated丨ISGylated

Subunit：Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3 (PubMed:21190939, PubMed:21642987, PubMed:39009378)

Synonyms

C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1; IFNAI1; ISG56; P56; RNM561

Documentación

User Guide for Antibodies (1077 KB)