IFN-γ/Interferon gamma Antibody (YA10047)
(Synonyms: IFN gamma, /Interferon gamma)
Based on 1 Customer Validation
IFN-γ/Interferon gamma Antibody (YA10047) is a Rat-derived and non-conjugated IgG1 Monoclonal antibody, targeting to IFN-γ/Interferon gamma gamma.
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Host:
Rat
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:50-200 | 1:500-2000 |
Product Details
IFN-γ/Interferon gamma Antibody (YA10047) is a Rat-derived and non-conjugated IgG1 Monoclonal antibody, targeting to IFN-γ/Interferon gamma gamma.
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Host Rat
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Clonality Monoclonal
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Species ReactivityMouse
E. coli-expressed, recombinant mouse IFNG
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IFN-γ (Interferon-gamma) is a key immune cytokine produced by NK cells, Th1 cells, and CD8⁺ T cells. It regulates macrophage activation, Th1 differentiation, antigen presentation, and anti-tumor immunity via the IFNGR-JAK-STAT1 pathway. IFN-γ serves as an important indicator for assessing cellular immune function, T-cell activation status, and the efficacy of immunotherapy.
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Mainly released by activated T lymphocytes
Induction:By cytokines, most notably interleukin IL-12, secreted by professional antigen-presenting cells such as monocytes/macrophages and dendritic cells -
Subunit
Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization
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SwissProt ID
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Synonyms
IFN gamma, /Interferon gamma
Documentation
References
[1]. Pearl JE, et al. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell Immunol. 2001 Jul 10;211(1):43-50. [Content Brief]
[2]. Huang S, et al. Immune response in mice that lack the interferon-gamma receptor. Science. 1993 Mar 19;259(5102):1742-5. [Content Brief]
[3]. Baldridge MT, et al. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10;465(7299):793-7. [Content Brief]
[4]. Matatall KA, et al. Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Stem Cells. 2014 Nov;32(11):3023-30. [Content Brief]
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