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Cat. No.: HY-P84841A

IL1RAPL1 Antibody (YA4538)(PBS only)

Name: IL1RAPL1 Antibody (YA4538)(PBS only)
Brand: MedChemExpress
SKU: HY-P84841A
Availability: PreOrder

(Synonyms: IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2)

IL1RAPL1 Antibody (YA4538) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL1RAPL1.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	FC FC: Flow Cytometry	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:200-1:400	1:10000

Description

IL1RAPL1 Antibody (YA4538) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL1RAPL1.

Host Mouse
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 80 kDa

Immunogen

Purified recombinant fragment of human IL1RAPL1 (AA: 541-694) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

IL1RAPL1 may regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD^[1]^[2].
Subcellular Localization

Cell membrane; Single-pass type I membrane protein; Cytoplasm; Cell projection, axon; Cell projection, dendrite
Expression

Tissue_specificity:Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver
Isoforms & Post-Translational Modification

Q9NZN1 has 1 isomers: Q9NZN1-1: 79969 Da (predicted).
Subunit

Homodimer (PubMed:15123616). Interacts (calcium-independent) with NCS1 (PubMed:12783849). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (By similarity)
SwissProt ID

Q9NZN1
Gene ID

11141 [NCBI]
Synonyms

IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2