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gamma Catenin Antibody (YA3801)

(Synonyms: DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12)
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Based on 1 Customer Validation

gamma Catenin Antibody (YA3801) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to gamma Catenin.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for gamma Catenin Antibody (YA3801)
  • gamma Catenin Antibody (YA3801) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:200-1:1000 1:200-1:1000 1:10000

Product Details

Description

gamma Catenin Antibody (YA3801) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to gamma Catenin.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 82 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 82 kDa
Immunogen

Purified recombinant fragment of human JUP aa 534-740.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3718836

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for gamma Catenin Antibody (YA3801)
    Western blot analysis of extracts from MCF-7(lane 2(20μg), A431(lane 3(20μg), HeLa(lane 4(20μg), HCT116(lane 5(20μg) using gamma Catenin Antibody (HY-P84104). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hours at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004, 1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    gamma Catenin is a Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton

  • Subcellular Localization

    Cell junction, adherens junction; Cell junction, desmosome; Cytoplasm, cytoskeleton; Cell membrane; Peripheral membrane protein; Cytoplasm; Cell junction; Nucleus

  • Expression


    Tissue_specificity:Expression in the heart (protein level)

  • Subunit

    Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions.

  • SwissProt ID

    P14923

  • Gene ID
    3728 [NCBI]
  • Synonyms

    DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12

gamma Catenin Antibody (YA3801) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from MCF-7(lane 2(20μg), A431(lane 3(20μg), HeLa(lane 4(20μg), HCT116(lane 5(20μg) using gamma Catenin Antibody (HY-P84104). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hours at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004, 1/10,000) was used for 1 hour at room temperature.

  • gamma Catenin Antibody (YA3801) Product Image
    1/16
  • Experimental Validation Results for gamma Catenin Antibody (YA3801)
  • gamma Catenin Antibody (YA3801) Product Image
  • Experimental Validation Results for gamma Catenin Antibody (YA3801)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from MCF-7(lane 2(20μg), A431(lane 3(20μg), HeLa(lane 4(20μg), HCT116(lane 5(20μg) using gamma Catenin Antibody (HY-P84104). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hours at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004, 1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for gamma Catenin Antibody (YA3801)
  • gamma Catenin Antibody (YA3801) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from MCF-7(lane 2(20μg), A431(lane 3(20μg), HeLa(lane 4(20μg), HCT116(lane 5(20μg) using gamma Catenin Antibody (HY-P84104). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hours at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993, 1/10,000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004, 1/10,000) was used for 1 hour at room temperature.

  • gamma Catenin Antibody (YA3801) Product Image WB