KCNJ3 (GIRK1 ) Antibody (YA8284)
(Synonyms: GIRK1; KGA; KIR3.1)KCNJ3 (GIRK1 ) Antibody (YA8284) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KCNJ3 (GIRK1 ).
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Monkey, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
KCNJ3 (GIRK1 ) Antibody (YA8284) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KCNJ3 (GIRK1 ).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Monkey, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 56.4 kDa
Human recombinant protein fragment corresponding to amino acids 279-501 of human KCNJ3 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KCNJ3 is an Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. This receptor plays a crucial role in regulating the heartbeat[1][2].
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Subcellular Localization
Membrane
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Isoforms & Post-Translational Modification
P48549 has two isomers: P48549-1: 56603 Da (predicted); P48549-2: 26829 Da (predicted).
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Subunit
Associates with KCNJ5/GIRK4 or KCNJ6/GIRK2 to form a G-protein activated heteromultimer pore-forming unit
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SwissProt ID
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Synonyms
GIRK1; KGA; KIR3.1
Documentation
References
[1]. Schoots O, et al. Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. Brain Res Mol Brain Res. 1996 Jul;39(1-2):23-30. [Content Brief]
[2]. Chan KW, et al. A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. J Gen Physiol. 1996 Mar;107(3):381-97. [Content Brief]
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