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  5. LIGHT/TNFSF14 Antibody (YA1512)

LIGHT/TNFSF14 Antibody (YA1512)

Cat. No.: HY-P81767
User Guide for Antibodies Technical Support

LIGHT/TNFSF14 Antibody (YA1512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIGHT/TNFSF14.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
50 μL Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
100 μL Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

LIGHT/TNFSF14 Antibody (YA1512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIGHT/TNFSF14.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 26 kDa;
Observed band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant human LIGHT protein
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
1:50-1:100
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304)
Subcellular Localization：Cell membrane; Single-pass type II membrane protein; Secreted; Cytoplasm
Expression：
Tissue_specificity:It is primarily expressed in the spleen, but also found in brain tissue. Expression is weaker in peripheral lymphoid tissues, as well as in the heart, placenta, liver, lungs, appendix, and kidneys. It has not been observed in fetal tissues, endocrine glands, or non-hematopoietic tumor cell lines.

Induction:Up-regulated after T-cell activation
Isoforms & Post-Translational Modification：O43557 has 2 isomers: O43557-1: 26350 Da (predicted); O43557-2: 22395 Da (predicted).
N-glycosylated;The soluble form of isoform 1 derives from the membrane form by proteolytic processing
Subunit：Homotrimer. Interacts with TNFRSF14
Database

Entrez Gene: 8740 Human

SwissProt: O43557 Human

OMIM: 604520 Human

Research Field

Immunology
Synonyms
TNFSF14; CD258; HVEML; LIGHT; LTg
Documentation
User Guide for Antibodies (1077 KB)

LIGHT/TNFSF14 Antibody (YA1512) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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LIGHT/TNFSF14 Antibody (YA1512)
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