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LRRC25 Antibody (YA8483)(PBS only)

(Synonyms: MAPA)
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LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • LRRC25 Antibody (YA8483)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:2000 1:150-500 1:100-250 1:100

Product Details

Description

LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 33 kDa
Immunogen

Full length human recombinant protein of human LRRC25 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    LRRC25 plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA[1].

  • Subcellular Localization

    Membrane,Cytoplasm

  • Expression


    Tissue_Specificity: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus
    Induction: Down-regulated in CD40-activated monocyte-derived dendritic cells

  • Isoforms & Post-Translational Modification

    Q8N386: 305 amino acids, molecular weight 33179 Da.

  • Subunit

    Interacts with RIGI (PubMed:29288164)

  • SwissProt ID

    Q8N386

  • Synonyms

    MAPA

LRRC25 Antibody (YA8483)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • LRRC25 Antibody (YA8483)(PBS only) Product Image