LRRC25 Antibody (YA8483)(PBS only)

Cat. No.: HY-P88799A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LRRC25 Antibody (YA8483) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LRRC25.

Host

Mouse

Molecular Weight

Predicted band size: 33 kDa

Species Reactivity

Human

SwissProt ID

Q8N386

Immunogen

Full length human recombinant protein of human LRRC25 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA

Subcellular Localization：Membrane,Cytoplasm

Expression：
Tissue_Specificity: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus
Induction: Down-regulated in CD40-activated monocyte-derived dendritic cells

Isoforms & Post-Translational Modification：Q8N386: 305 amino acids, molecular weight 33179 Da.

Subunit：Interacts with RIGI (PubMed:29288164)

Synonyms

MAPA

Documentation

User Guide for Antibodies (1077 KB)