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  5. MGRN1 Antibody (YA8516)(PBS only)

MGRN1 Antibody (YA8516)(PBS only)

Cat. No.: HY-P88832A
User Guide for Antibodies Technical Support

MGRN1 Antibody (YA8516) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MGRN1.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

MGRN1 Antibody (YA8516) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MGRN1.
Host

Mouse
Molecular Weight

Predicted band size: 63 kDa
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Immunogen

Full length human recombinant protein of human MGRN1 produced in HEK293T cell.
Application &
Dilution Ratio
Application Dilution Ratio
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:100-250
FC
FC: Flow Cytometry
1:100
Purity Affinity purified Conjugation Non-conjugated
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity)
Subcellular Localization：Early endosome,Cytoplasm, cytosol,Nucleus,Cytoplasm, cytosol,Nucleus,Cytoplasm, cytosol,Cell membrane,Cytoplasm, cytosol,Cell membrane
Isoforms & Post-Translational Modification：O60291 has four isomers: O60291-1: 60753 Da (predicted); O60291-2: 63190 Da (predicted); O60291-3: 60742 Da (predicted); O60291-4: 58305 Da (predicted).
Autoubiquitinated in vitro
Subunit：Interacts with MC1R and MC4R, but not with TBXA2R
Synonyms
RNF156
Documentation
User Guide for Antibodies (1077 KB)

MGRN1 Antibody (YA8516)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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