NRG3 Antibody (YA7299)
(Synonyms: Pro-NRG3, NRG3)
Based on 1 Customer Validation
NRG3 Antibody (YA7299) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NRG3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 | 1:50-100 |
Product Details
NRG3 Antibody (YA7299) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NRG3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Mouse
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 78 kDa
A synthesized peptide derived from human NRG3 aa 560-720 / 720.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NRG3 is a Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes
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Subcellular Localization
Cell membrane,Secreted,Cell membrane
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Expression
Tissue_Specificity: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes -
Isoforms & Post-Translational Modification
P56975 has four isomers: P56975-1: 77901 Da (predicted); P56975-2: 77164 Da (predicted); P56975-3: 56034 Da (predicted); P56975-4: 75031 Da (predicted).
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form丨Extensive glycosylation precedes the proteolytic cleavage (By similarity) -
Subunit
Interacts with ERBB4
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SwissProt ID
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Synonyms
Pro-NRG3, NRG3
Documentation
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