NSMCE2 (NSE2) Antibody (YA8067)
(Synonyms: C8orf36; MMS21; NSE2; ZMIZ7)NSMCE2 (NSE2) Antibody (YA8067) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSMCE2 (NSE2).
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
ICC/IF, FC
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
NSMCE2 (NSE2) Antibody (YA8067) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NSMCE2 (NSE2).
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 27.8 kDa
Full length human recombinant protein of human NSMCE2 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
NSMCE2 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression[1][2][3][4][5].
-
Subcellular Localization
Nucleus,Chromosome, telomere,Nucleus, PML body
-
Isoforms & Post-Translational Modification
Q96MF7: 247 amino acids, molecular weight 27932 Da.
-
Subunit
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3
-
SwissProt ID
-
Synonyms
C8orf36; MMS21; NSE2; ZMIZ7
Documentation
Powered by Bioz
